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Case No. 21: Aggressive Giant Cell Tumor

Aggressive Giant Cell Tumor


X-Ray Knee

Report Of Aggressive Giant Cell Tumor:

A highly destructive osteolytic lesion obliterates the cortical and
the medullary bone of the entire metaphysis and subchondral region of the distal portion of the femur. The matrix of the lesion is purely osteolytic, and a pathologic fracture with angulation is seen. A large soft tissue mass is evident. Marked osteopenia secondary to disuse is seen in the proximal portions of the tibia and fibula.

Differential Diagnosis:

  • Metastatic carcinoma (especially from kidney, thyroid, or lung, hepatoma).
  • Plasmacytoma.
  • Aggressive giant cell tumor.
  • Hemophilic pseudotumor.
  • Telangiectatic Osteosarcoma.
  • Fibrosarcoma.
  • Chondrosarcoma.


Aggressive giant cell tumor

Key Points:

More than 40% of aggressive giant cell tumors occur in the femur. Involve the knee and less commonly the hip
Eccentrically located, subarticular osteolytic lesion extending into the metaphysis. Cortical destruction and soft tissue mass are variable findings. Radiographic appearance is an inaccurate guide to determining malignancy of lesion; biopsy necessary.

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